How does Psilocybin work?
Psychedelics is a term that covers a broad range of compounds. Most are natural organic compounds from nature. Historically they have been used for the purposes of treating or alleviating the symptoms of a disease, ailment or injury.
Upon ingestion, psilocybin is rapidly converted to psilocin by the liver. Psilocin then connects into the serotonergic system and dampens the 'default mode network' or DMN which is so often responsible for repetitive thoughts and feelings of being 'looped' in a certain way of thinking, or a pattern of behaviour. The effect of psilocin allows for reflection and introspection via connecting parts of the brain in new and unique ways.
A mathematical representation showing the new routes of connections in a human brain:
a) without psilocybin and b) with psilocybin present in system
When watching the video above, most are surprised to learn that there are the same number of lines in both a) and b) -7200 to be exact. Brain a) is the conserving energy, What we are interested in is the dialogue which opens up between areas of the brain which previously in the DMN were not in communication with each other.
It is this key factor which creates an opportunity for healing in an individual using psilocybin treatment in conjunction with the guidance of a trained therapist.
What happens during psilocybin therapy?
The psychological support element of the therapy is considered to be as important as the pharmacological effects of psilocybin. All therapists will be carefully and meticulously trained through regulatory-approved programs.
Psychedelic assisted psychotherapy is currently being trialed worldwide and is demonstrating excellent results in treating depression, anxiety, addiction and post traumatic stress disorder; as well as providing promising leads into Chronic pain, Fibromyalgia, Addiction, Neurodegeneration, dementia, Alzheimer and anorexia.
Roland R. Griffiths, PhD speaks here about his 15 years of experience working at the John Hopkins psilocybin research project and the results they found from treating patients with psilocybin therapy.
“What we’re understanding now is that regardless of receptor-level pharmacology, the really interesting changes that occur with these compounds are in brain network dynamics— the way different areas of the brain communicate with each other.”
Mathew Johnson, Johns Hopkins University
The therapeutic effectiveness of most medicinal psychedelic compounds is not categorised as they have been illegal since the 60's; but recent clinical trials by John Hopkins University and Imperial College London are showing that they have significant therapeutic relevance and that we have 50 years of data and research to catch up on.
Psilocybin and Smoking Addictions
Psilocybin and End of Life Anxiety
MDMA and Post Traumatic Stress Disorder
Depression and Anxiety
Post traumatic stress disorder
Autism spectrum disorder
Substance use disorders
Migrane and cluster headaches
Alzheimer’s & Neurodegeneration
Health and Longevity